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Increasing the ΔΨ reduces the mitochondrial [NAD + ]/[NADH] that may slow aging (Berry et al., 2023a,b) by both enhancing SLC25A12 and SLC25A13 activity to increase MAS activity and by creating thermodynamic back-pressure to slow ETC complex I-mediated proton pumping

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Whole-cell patch-clamp recordings were performed on mRFP-β-actin-transfected hippocampal neurons to measure miniature excitatory postsynaptic currents (mEPSCs), reflecting synaptic activity [1]